Anti-Acetylated Lysine (monoclonal, clone 7F8)
SKU: BTL-AGR-A-00811 | Host: Mouse | Brand: Agrisera
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| Cat Number | AS10 707-100 |
|---|---|
| Category | Primary Antibody |
| Pack Size | 100 µl |
| Description | Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common posttranscriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3). |
| Applications | ELISA (ELISA), Immunocytochmistry/Immunofluorescence (ICC/IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western blot (WB) |
| Immunogen | acetylated KLH |
| Clonality | Monoclonal |
| Host | Mouse |
| Form | Liquid |
| Dilution Range | 1 : 100 (IHC), 1 : 1000 (WB) |
| Purity | Total IgG fraction. Protein G purified. |
| Specie Reactivity | Bovine, avian |
| Expected Reactivity | Higher plants |
| Storage | Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube. |
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| Note | The product is for research use only |