Anti-Transthyretin 56-61, amyloid specific (mouse monoclonal)
SKU: BTL-AGR-A-01588 | Host: Mouse | Brand: Agrisera
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| Cat Number | AS16 3113 |
|---|---|
| Category | Primary Antibody |
| Pack Size | 100 µg |
| Description | Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal disease characterized by amyloid depositions found in visceral organs including the heart, liver, and kidney. The wild type form of TTR is associated with a late onset amyloidosis denoted senile systemic amyloidosis, affecting around 10% of the population above 80 years of age with depositions mainly found in the heart.Monoclonal IgG1 antibody. Amyloid specific for human Transthyretin. Detects the C-terminal fragment 49-127 frequently formed in vivo. |
| Applications | ELISA (ELISA), Immunohistochemistry (IHC), Western blot (WB) |
| Immunogen | Recombinant protein corresponding to the Human wild type Transthyretin. GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE The epitope has been mapped to residue 56-61 |
| Clonality | Monoclonal |
| Host | Mouse |
| Form | Lyophilized |
| Molecular Weight | 155 |
| Dilution Range | 1:1000 (ELISA), 1:500 (IHC), 1:1000 (WB) |
| Purity | Affinity purified in PBS pH 7.4. |
| Specie Reactivity | Human Transthyretin Amyloids |
| Reconstitution | Add 100 µl sterile water to reconstitute to 1 mg/ml |
| Storage | Store lyophilized/reconstituted at 4°C, Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube. |
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| Note | The product is for research use only |