Anti-H3T3pK4ac | Histone H3 (ac Lys4, p Thr3)
SKU: BTL-AGR-A-01638 | Host: Rabbit | Brand: Agrisera
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| Cat Number | AS16 3170 |
|---|---|
| Category | Primary Antibody |
| Pack Size | 50 µg |
| Description | Chromatin is the arrangement of DNA and proteins in which chromosomes are formed. Correspondingly, chromatin is formed from nucleosomes, which are comprised of a set of four histone proteins (H2A, H2B, H3, H4) wrapped with DNA. Chromatin is a very dynamic structure in which numerous post-translational modifications work together to activate or repress the availability of DNA to be copied, transcribed, or repaired. These marks decide which DNA will be open and commonly active (euchromatin) or tightly wound to prevent access and activation (heterochromatin). Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, and sumoylation, biotinylation, and ubiquitylation of lysine. Phosphorylation of threonine 3 (H3T3p) is a known mitotic marker and modified by the Haspin/Thr3 enzyme, while acetylation of lysine 4 (H3K4ac) on histone 3 is associated with transcriptional activation by Esa1. Alternative names: H3.3B, H3 histone, family 3A, H3.3AH3F3H3F3B, histone H3.3, MGC87782, MGC87783, H3pT3/K4ac . |
| Applications | Chromatin immunoprecipitation (ChIP), Dot blot (Dot), Immunofluorescence (IF), Immunohistochemistry (IHC), Western blot (WB) |
| Immunogen | KLH-conjugated synthetic acetylated/phosphorylated peptide surrounding Lysine 4 and Threonine 3 of human Histone H3 |
| Clonality | Polyclonal |
| Host | Rabbit |
| Form | Liquid |
| Molecular Weight | 15 kDa |
| Dilution Range | 2-5 µg/million cells (ChIP), 1 : 1000 (Dot), 1 : 100 (IF), 1 : 50 (IHC), 1 : 500 (WB) |
| Uniprot Number | Q71DI3 |
| Purity | Immunogen affinity purified serum. |
| Specie Reactivity | Caenorhabditis elegans, Human |
| Expected Reactivity | Chicken, Drosophila melanogaster, Mouse, Plant, Rat, Xenopus sp. |
| Storage | Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube. |
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| Note | The product is for research use only |